In October 2021, a major COVID-19 vaccination campaign took place in Jiñocuao, Nicaragua, where TPPC has a sister parish relationship with San José Church. The campaign included adults, young people, and children, and was the first time COVID vaccines have been made available in Jiñocuao.

As of October 29, 2021, 5.5% of Nicaraguans have been fully vaccinated, according to Reuters.